Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer
Status:
Completed
Trial end date:
2015-05-14
Target enrollment:
Participant gender:
Summary
NAC is the N-acetyl derivative of the naturally occurring amino acid, L-cysteine. It is a
common over-the-counter supplement and also is available as an injectable pharmaceutical that
protects the liver in cases of acetaminophen overdose. In the exercise physiology literature,
both oral and injectable NAC have been shown to reduce fatigue and improve recovery from
exertion which has interesting implications for exploring cancer-related fatigue.
In terms of cancer cell biology, reactive oxygen species (ROS) may play an important role in
the development and progression of breast cancer
Phase:
Phase 1
Details
Lead Sponsor:
Sidney Kimmel Cancer Center at Thomas Jefferson University Thomas Jefferson University