Pilot Study of Atorvastatin in Children With Chronic Hyperlipidemia Secondary to Nephrotic Syndrome
Status:
Terminated
Trial end date:
1999-12-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES:
I. Determine the effect of atorvastatin on the plasma levels of lipids, Lp(a), and
apoproteins for treating hyperlipidemia in children with nephrotic syndrome in whom
proteinuria and hyperlipidemia persist after other appropriate measures to treat their
primary disease have been exhausted.
II. Determine the safety and tolerability of atorvastatin in these patients.
III. Provide preliminary data for a future investigation into the potential effect that
lowering cholesterol levels may have on the rate of progression of renal insufficiency in
such patients.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)