Pilot Study of Green Tea Extract (Polyphenon E®)in Ulcerative Colitis
Status:
Completed
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
Green tea consists of several components, with most research focusing on the polyphenol
fraction. The polyphenol fraction(-)-epigallocatechin-3-gallate (EGCG)has been studied
extensively as an anti-inflammatory agent as well as a preventative agent for cancer. It has
been shown to effectively reduce the inflammation associated with animal models of
inflammatory bowel disease. This clinical trial will determine the ability of EGCG, in the
form of Polyphenon E®, to treat patients with mild to moderately severe ulcerative colitis.
Phase:
Phase 2
Details
Lead Sponsor:
University of Louisville
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)