Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis
Status:
Completed
Trial end date:
2021-06-22
Target enrollment:
Participant gender:
Summary
Individuals with kidney failure receiving maintenance hemodialysis (HD) have high mortality
rates, driven largely by cardiovascular causes. Volume-related factors are critical,
modifiable contributors to cardiovascular complications. Reversing volume overload has been
shown to improve blood pressure and cardiac remodeling. Use of loop diuretics may represent a
pragmatic, low-cost, and low-burden strategy to improve outcomes in people receiving HD. Lack
of data on optimal furosemide dosing, safety, and acceptability are barriers to expanded use.
This study investigates whether oral furosemide is safe and effective at increasing urine
volume in HD patients.
Phase:
Phase 2
Details
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)