Overview
Pilot Study of Sodium Nitrite in Resuscitated Cardiac Arrest Patients
Status:
Completed
Completed
Trial end date:
2016-04-01
2016-04-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Despite advances in cardiac arrest resuscitation survival from cardiac arrest is less than 20-30% and new therapies are urgently needed. Sodium nitrite infused during resuscitation from cardiac arrest has recently been shown to improve survival in a mouse model of cardiac arrest and our group is eager to test this hypothesis in a clinical trial. Our overall hypothesis is that an infusion of 2 μmole/kg sodium nitrite during resuscitation will increase the proportion of patients who will survive cardiac arrest. In preparation for a clinical trial, preliminary safety and efficacy data (phase 1) is needed which is the primary goal of this study.Phase:
Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
University of WashingtonCollaborator:
Medic One Foundation
Criteria
Inclusion Criteria:- Successfully resuscitated from cardiac arrest by paramedics in the field Age 18 or
older Comatose IV access
Exclusion Criteria:
- traumatic cause of cardiac arrest known DNAR Patient requiring vasopressors at time of
randomization SBP <105 PaO2 of less than 90% on FiO2 of 1.0