Pilot Study of Terazosin in Treatment of Antidepressant Induced Excessive Sweating

• Status: Completed
• Trial end date: 2007-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is based on the hypothesis that terazosin, a blocker of alpha-1 receptors, will be effective in reducing excessive sweating caused by antidepressant treatment, and will have minimal adverse effects.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thomas Jefferson University
• Treatments: Antidepressive Agents; Prazosin; Terazosin

Criteria

Inclusion Criteria:

• Clinical diagnosis of a Depressive disorder (Diagnostic and Statistical Manual of Mental Disorders - IV-TR)

• Presence of excessive sweating by self-report

• The excessive sweating started after initiation of an antidepressant and, if treatment with the antidepressant was interrupted, did not persist for more than 4 weeks during that interruption

• Treatment with the antidepressant is deemed to be clinically necessary due to substantial benefit from this antidepressant, and failure to respond to or tolerate an alternative

• Excessive sweating has persisted for at least 4 weeks prior to baseline assessment

• The excessive sweating is rated by the patient as at least moderately bothersome.

• Episodes of excessive sweating occur at least twice a week for last 4 weeks

Exclusion Criteria:

• Presence of another known disease that could potentially cause excessive sweating

• Failure to respond to antiadrenergic (reducing activity of the sympathetic nervous system) treatment in the past

• Blood pressure less than 110 mm Hg systolic at the screening or baseline visits

• Orthostatic hypotension by history or on assessment at the screening or baseline visits (defined as a decrease of 10 mm Hg or greater after standing for 2 minutes).

• Current antihypertensive treatment

• History of significant cardiac disease, including coronary artery disease

• Current use of phosphodiesterase type 5 inhibitors: sildenafil (Viagra™), tadalafil (CialisTM), or vardenafil (LevitraTM)

• History of priapism (persistent and painful erection)