Pilot Study on the Use of Sirolimus to Treat Chronic Allograft Nephropathy in Children After Kidney Transplant
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether treatment with sirolimus, in combination
with low-dose tacrolimus and prednisone, is effective for the treatment of chronic allograft
nephropathy (progressive scarring) in children who have previously received a kidney
transplant. This treatment is compared to the standard therapy which uses low-dose
tacrolimus, mycophenolate mofetil and prednisons.
This study is a pilot study that will determine whether treatment with sirolimus reduces or
improves the rate of scarring seen on kidney biopsy of the transplanted kidney over time,
compared to children who continue to be treated with mycophenolate mofetil.