Pilot Study to Evaluate a Method of Controlling High Blood Sugar in the Pediatric Intensive Care Unit
Status:
Completed
Trial end date:
2006-03-01
Target enrollment:
Participant gender:
Summary
Recent studies of adult intensive care unit (ICU) patients have shown significantly decreased
morbidity and mortality when blood sugar concentrations are closely controlled. The safety
and efficacy of this type of blood sugar management has not been studied in the pediatric ICU
population. Based on the current pediatric literature data as well as our extensive
retrospective study, blood sugar concentrations have a potentially profound role to play
among PICU patients. In preparation for a multi-center randomized control trial, we propose a
prospective feasibility study to evaluate the safety and effectiveness of using an insulin
delivery algorithm to manage blood sugar in the PICU. Our hypothesis for this feasibility
trial is that uniformly monitoring and controlling blood glucose with a
Discrete-Closed-Loop(DCL) insulin delivery algorithm will be an effective, safe, and
consistent means of delivering insulin to manage glucose in the pediatric intensive care
unit.