Pioglitazone Decreases Visceral Fat Metabolism

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Excess visceral fat is associated with chronic systemic inflammation and cardiovascular complications. Pioglitazone has been reported to variably influence visceral fat volume, but it its effect on metabolic activity of the visceral fat remains uncharacterized. To evaluate the effect of pioglitazone on glucose metabolism of fat tissue by using 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and computed tomography (CT) imaging.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Kurume University
• Treatments: Glimepiride; Pioglitazone

Criteria

Inclusion Criteria:

• Subjects between the ages of 35 and 85 years

• Subjects with impaired glucose tolerance and type 2 diabetes

Exclusion Criteria:

• Subjects with insulin treatment

• Subjects with uncontrolled diabetes, hypertension, symptomatic coronary artery disease, symptomatic cerebrovascular disease

• Subjects taking more than three antidiabetic medications

• Subjects taking anti-platelet, statins, antidiabetic agents, thiazolidinediones within 8 weeks prior to randomization

• Subjects with cardiac failure (New York Heart Association Class > III) or left ventricular dysfunction (LVEF < 40%)

• Subjects with systemic disorders such as active inflammatory, liver, renal, hematopoietic, and malignant disease