Pioglitazone as an Adjunct for Moderate to Severe Depressive Disorder

• Status: Completed
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Pioglitazone as an adjunct to Citalopram is effective in treatment of moderate to severe depression

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tehran University of Medical Sciences
• Treatments: Chlordiazepoxide; Citalopram; Dexetimide; Pioglitazone

Criteria

Inclusion Criteria:

• Diagnosis of Major depressive disorder based on DSM-IV TR criteria

• Age 18-50

• Hamilton Depression Rating scale >=22

• Signing the informed consent form

• Citalopram be the drug of choice for the patient irrespective of other eligibility criteria

Exclusion Criteria:

• Problems in other Axes

• Pregnancy and lactation

• Serious or life threatening disease

• taking other antidepressant in the recent month or Electroconvulsive shock in the recent two months, and taking other psychotropic agents

• Diabetes controlled with drugs or insulin (patients with only lifestyle interventions will be included), Liver disease, Congestive heart failure Class III and IV

• Metabolic syndrome