Pistachios Blood Sugar Control, Heart and Gut Health

• Status: Recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

A two-period randomized crossover study will be conducted to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk factors for heart disease. This study will also investigate how pistachios affects gut health.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Penn State University

Criteria

Inclusion Criteria:

• BMI ≥25 and ≤45 kg/m2

• Fasting plasma glucose 100 - 125 mg/dL

• non-Smoking

Exclusion Criteria:

• Diagnosed diabetes or fasting glucose >126 mg/dl

• Systolic blood pressure >160mmHg or diastolic blood pressure >100mmHg)

• Prescribed anti-hypertensive, lipid lowering or glucose lowering drugs

• Established cardiovascular disease, stroke, diabetes, liver, kidney or autoimmune disease or inflammatory conditions

• Use of supplements (psyllium, fish oil, soy lecithin, phytoestrogens) and botanicals and not willing to cease for the duration of the study

• Women who are pregnant, lactating, planning to become pregnant or have given birth in the past year

• Weight loss of >=10% of body weight within the 6 months prior to enrolling in the study

• Smoking or use of any tobacco products

• Allergy/intolerance/sensitive to pistachios

• Consumption of >14 alcoholic drinks/week

• Shift-workers and those who cannot consume a snack in the evening