Pitocin or Oral Misoprostol for PROM IOL

• Status: Recruiting
• Trial end date: 2022-09-30
• Target enrollment: 0
• Participant gender: Female

Summary

Premature rupture of membranes (PROM) is a common occurrence of pregnancies at term. A delay from PROM to labor is associated with an increased risk of intrauterine infection and associated maternal and fetal morbidity; therefore, induction of labor (IOL) is recommended. The ideal agent for IOL is not known, particularly among specific subpopulations. The primary aim of this study is to determine if oxytocin (Pitocin) or oral misoprostol results in a shorter interval to delivery after the start of induction among nulliparous women with unfavorable cervical exams with term PROM.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pennsylvania
• Treatments: Misoprostol; Oxytocin

Criteria

Inclusion Criteria:

• English Speaking

• PROM
• >/= 36 weeks gestation

• Agreeable to induction of labor

• Nulliparous

• Singleton pregnancy

• Vertex presentation

• Cervical dilation Exclusion Criteria:

• Prior cesarean section

• Other contraindication to vaginal delivery

• Intrauterine Fetal Demise

• Major Congenital Anomaly

• Intraamniotic infection diagnosed at time of admission

• 36 weeks - 36 weeks and 6 days with unknown GBS status