Pitolisant Effects on Affect and Cognition Exploratory Study (PEACE Study)
Status:
Recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
The goal of this study is to investigate the effects of selective histamine 3 antagonist
pitolisant on brain function and cognition in healthy individuals. The main questions it aims
to answer are:
1. Does pitolisant alter functional activity in brain regions linked to reward and
cognitive processing during rest or cognitive task performance?
2. Does pitolisant alter cognitive ability across a range of psychological domains,
including working memory, executive functioning and emotional processing?
Participants will undertake fMRI scanning in addition to a battery of tasks designed to
measure cognitive and emotional processing after taking a single dose of pitolisant or
placebo. Researchers will compare differences in functional activity, cognition and emotional
processing across the pitolisant and placebo groups.