Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry

• Status: Completed
• Trial end date: 2019-03-15
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study is to assess the metabolic impact of Continuous Renal Replacement Therapy and overview the obstacles and important factors compromising the use of Indirect Calorimetry in CRRT and suggest a model to overcome these issues.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitair Ziekenhuis Brussel
• Treatments: Citric Acid; Micronutrients; Sodium Citrate; Trace Elements

Criteria

Inclusion Criteria:

• AKI requiring CRRT

• Patient on CRRT who's filter you want to change

• Expected stable patient during the test ( +- 2h) evaluated at discretion of physician :

• No alteration in medication

• Stable respiratory settings where no change in conditions is expected. If possible, controlled mode ventilation is preferred.

• Expected stable pH and lactate

• no intervention will be made on patient (transport/washing/physiotherapy/…)

• no alterations on settings of CRRT is expected to be made.

• Maximal respiratory settings: max FiO2: 60% / max inspiratory plateau pressure 30 mmHg/max tidal volumes 8ml/kg

• pH between 7,30-7,50, lactate levels <2,0

• starting settings CRRT with citrate:

• Blood pump flow: 150 ml/min

• Predilution ( citrate): 1500-2300ml/h

• Dialysate dose: 25-40 ml/kg/h

• ultrafiltration: 0-300 ml /h

• Substitution: NaCl 300-800 ml/h or B22: 400-2000 ml/h

Exclusion Criteria:

• Pregnancy / lactation

• Contra-indications for the use of indirect calorimetry as stated by the AARC (FiO2>60%, chest tubes)

• Severe hemodynamic or ventilator instability.

• CRRT modalities unusual to daily clinical ICU practice