Platelet Enzymatically Oxidized Phospholipids (eoxPL) Characterisation in a Healthy Cohort on and Off Aspirin
Status:
Completed
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
Healthy volunteers (n = 28) were recruited from the workplace (14 male, 14 female; age range
20-50 years). Ethical approval, which included informed consent, was from Cardiff University,
Schools of Medicine and Dentistry Research Ethics Committee (SMREC16/02). Following a 2-week
period free from non-steroidal anti-inflammatory drugs (NSAIDs), peripheral blood was
obtained and platelets isolated. Participants were commenced on aspirin 75 mg once daily for
seven days and then provided a repeat blood sample. Following a 2-month period, participants
were invited to repeat samples pre- and post-aspirin, and again a third time 2 months later.