Overview
Platelet Reactivity With Fentanyl, Morphine, or no Narcotic
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2023-06-01
2023-06-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort. Morphine has been shown to worsen outcomes in heart attack patients due to reduction of oral anti-platelet agent effectiveness and so many providers have switches to using fentanyl. However, it is largely unknown whether fentanyl has similar effects.Phase:
Early Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Spectrum Health - LakelandTreatments:
Fentanyl
Morphine
Criteria
Inclusion Criteria:- Adult Emergency Department patients undergoing 0 and 2 hour troponin testing
- administered aspirin within 30 minutes of the initial blood draw.
- patient presented via private vehicle
- provide informed consent
Exclusion Criteria:
- Patients not expected to get a 2 hour troponin;
- patients already on aspirin, clopidogrel, or stronger anti-coagulants;
- patients who arrived via EMS (Emergency Medical Services) given it can be difficult to
find the run reports to determine whether patient received fentanyl in the
pre-hospital period;
- pregnant patients;
- patients on chronic narcotics;
- patients already once enrolled in this study,
- inability to provide consent in English