Platelet Rich Plasma Injection for Knee Osteoarthritis
Status:
Completed
Trial end date:
2020-01-01
Target enrollment:
Participant gender:
Summary
The research questions of this study are;
1. Is platelet rich plasma (PRP) treatment effective in knee osteoarthritis (OA)?
2. What are the indications for PRP treatment?
3. Which patients are the most suitable for the PRP treatment method?
4. How does age, Body Mass Index (BMI), lower extremity mechanical axis angle and OA stages
affect the success of the PRP treatment?
5. Is there any advantage of multiple PRP doses?
6. What is the therapeutic effect of placebo?
This study was designed to find answers of these questions.
The hypotheses of this study are; "PRP treatment is more effective than placebo; PRP
treatment effectiveness decreases with age and advanced stages of OA; BMI is a factor that
negatively affects the treatment effectiveness of the PRP; as the mechanical axis angle of
the lower limb increases, it will adversely affect the effectiveness of PRP therapy; multiple
dose of PRP affects the effectiveness and duration of PRP as positively compared to single
dose of PRP".
The primary purpose of this study; to prove the effectiveness of PRP treatment on knee pain
and functions in patients with knee OA by comparing it with the placebo control group.
Secondary purposes of this study; to understand the effect of age, BMI, OA grade and lower
limb mechanical axis angle on PRP effectiveness. This study, designed as a randomized,
double-blind and placebo control group, with a high level of scientific evidence. Thus, it
will be scientifically possible to find answers to the investigators research questions and
to prove the investigators hypothesis.