Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Severe hemophilia is characterized by frequent and lifelong bleeding, with more than 60% of bleeds occurring into joints . Repeated joint bleeding leads to chronic synovitis, cartilage damage and bony destruction. Currently available treatment of hemophilic arthropathy, such as analgesics, NSAIDs, and hyaluronic acid (HA), are predominantly directed toward the symptomatic relief of pain and inflammation, but they do little to reduce joint cartilage degeneration.

Platelet-Rich Plasma (PRP) is a simple and minimally invasive method that provides a natural concentrate of autologous growth factors from the blood. This method is now being increasingly applied in clinical practice to treat musculoskeletal disorders, such as tendon repairment and osteoarthritis. To the best of our knowledge, no study applies PRP for arthropathy of knee joint in hemophilia patients. The aim of the study is to investigate the efficacy, safety and duration of benefit of single PRP injection versus five weekly intra-articular injections of HA in patients with hemophilic arthropathy of knee.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tri-Service General Hospital
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• hemophilia patients with hemophilic arthropathy of knee joints for at least 6 months

• painful (VAS ≥ 3) hemophilic arthropathy of knee joints after medication

Exclusion Criteria:

• presence of joint infections, any surgery on the joint in preceding 12 months

• intra-articular corticosteroid or HA injection within the past 6 months

• treatment with systemic steroids

• history of rheumatoid arthritis, or gouty arthropathy

• history of chicken or egg allergy

• presence of neoplasm

• use of non steroidal anti-inflammatory drugs in the 5 days before study

• platelet values < 100,000/mm3

• acute hemarthrosis

• paresis, or recent trauma.