Platinum for Triple-Negative Metastatic Breast Cancer and Evaluation of p63/p73 as a Biomarker of Response

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to :

• Determine how effective cisplatin or carboplatin is in slowing the time it takes for ER negative (estrogen-receptor-negative), PR negative (progesterone receptor-negative), HER2 negative (human epidermal growth factor receptor 2) breast cancer to progress. Cisplatin and carboplatin are anti-cancer chemotherapy drugs that stop cancer cells from growing abnormally and is used to treat other cancers.

• Evaluate a new biomarker to help determine which breast cancers are most likely to respond to cisplatin chemotherapy

The hypothesis is that Triple Negative metastatic breast cancer may be particularly sensitive to platinum, and that a subgroup of those patients may have a marker in their tumors that predicts response.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborators: Beth Israel Deaconess Medical Center; Dana-Farber Cancer Institute; North Shore Medical Center
• Treatments: Carboplatin; Cisplatin

Criteria

Inclusion Criteria:

• Histologically confirmed invasive breast cancer with stage IV disease, according to AJCC 6th edition (American Joint Committee on Cancer), either biopsy proven or with unequivocal evidence of metastatic disease by physical examination or radiological study

• All tumors must be ER-, PGR- and HER2-negative

• 18 years of age or older

• Paraffin tissue block is required from the primary tumor tissue or from diagnostic metastatic biopsy at time of relapse

• Measurable disease by RECIST

• Performance status of 0,1 or 2 by ECOG criteria (Eastern Cooperative Oncology Group)

• Life expectancy greater than 12 weeks

• Normal organ and bone marrow function documented within 14 days prior to enrollment as defined by the protocol

Exclusion Criteria:

• More than 1 prior chemotherapy for the treatment of recurrent or metastatic breast cancer

• Prior treatment with cisplatin, carboplatin, or other platinum chemotherapy agents

• Active brain metastases or unevaluated neurological symptoms suggestive of brain metastases

• Intercurrent illness or other major medical condition or comorbid condition that might affect study participation

• Significant history of uncontrolled cardiac disease such as uncontrolled hypertension, unstable angina, recent myocardial infarction, uncontrolled congestive heart failure, cardiomyopathy either symptomatic or asymptomatic but with decreased ejection fraction <45%

• Renal dysfunction for which cisplatin dose would either require dose modification or would be considered unsafe

• Pregnant or nursing women

• History or other malignancy that was not treated with curative intent