Pneumococcal Conjugate Vaccine in Aging Renal Transplant
Status:
Terminated
Trial end date:
2020-02-28
Target enrollment:
Participant gender:
Summary
The goal of the research proposed in the current application is to first define how much
antibody aging renal transplant and dialysis recipients make after they are vaccinated with
the pneumonia vaccine and how this compares to similar aged persons with good renal function
and healthy young adults. The investigators will study differences in the kind of B cells and
markers on the B cells that are known to be important in the response to the pneumonia
vaccine in aging renal transplant and aging dialysis recipients compared to similarly aged
and young healthy controls. Finally, the investigators will study how safe the pneumonia
vaccine is in aging renal transplants. The answers to these questions will help in designing
a better vaccine for older people with a renal transplant or on dialysis.