Polyethylene Glycol Cleansing in Patients at High Risk for Poor Bowel Preparation
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
The aim of this randomized trial is to compare the proportion of patients achieving an
adequate bowel preparation after a 1-day split-dose 4-liter PEG-based bowel preparation
regimen (Golytely, Braintree Laboratory Inc, MA, USA) vs. the same regimen given on 2
consecutive days in a population identified as high risk for an inadequate bowel preparation.
2. Research Design: This study is a single-center prospective randomized study at the West
Haven VAMC.
3. Methodology:
1. Primary endpoint: Adequate bowel preparation as defined by a Boston Bowel Preparation
Scale (BBPS) score of 2 or 3 (on scale of 0-3) in all 3 colon segments (left,
transverse, and right).
2. Secondary endpoints: Adenoma detection rate, polyp detection rate, sessile serrated
polyp/adenoma detection rate, patient tolerability of preparation using the validated
Mayo clinic bowel prep tolerability questionnaire, adverse events potentially related to
bowel preparation
Patients scheduled for routine outpatient colonoscopy will be eligible if they are at high
risk for poor bowel preparation,