Population Pharmacokinetic-Pharmacodynamic Study of Intravenous Oxycodone in Children
Status:
Suspended
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Oxycodone has been in clinical use for decades. It is an effective alternative to morphine
for moderate to severe acute or chronic pain and has been found to improve quality of life.
The drug has been used parenterally or orally as perioperative analgesia or for cancer pain
relief. Despite its long clinical experience, prescribing errors and misuse may lead to
addiction and accidental overdose. Currently, little is known about the pharmacokinetic
properties of intravenous oxycodone among paediatric patients in this region even though the
drug has been used in children in other countries such as Finland. Therefore, a
pharmacokinetic-pharmacodynamic study of oxycodone among Malaysian pediatric patients is
warranted.