Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection
Status:
Recruiting
Trial end date:
2021-09-01
Target enrollment:
Participant gender:
Summary
Propofol is a widely used sedative anesthetic, but there are large individual differences,
which making different patients with different sensitivity to propofol. The aim of this study
was to analyze the effects of age, height, body weight, Drinking, metabolic enzymes CYP2B6
and UGT1A9 on Pharmacological effects and pharmacokinetics of propofol, and to provide a
reasonable reference for clinical anesthesia patients and evidence for individual dosage
regimens.