Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter

• Status: Unknown status
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The study at hand is the first to investigate ketamine's SERT binding in humans, by utilizing the highly selective SERT radioligand [11C]DASB and positron emission tomography.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical University of Vienna
• Treatments: Antidepressive Agents; Esketamine; Ketamine; Serotonin

Criteria

Inclusion Criteria:

• 18-55 years

• somatic health

• severe unipolar depression according to DSM-IV (SCID) und HAM-D (for patients)

• capable of giving informed consent

• negative pregnancy test (females)

Exclusion Criteria:

• severe somatic illness

• psychiatric disorder (for healthy controls)

• an axis I comorbidity other than MDD , other than anxiety symptoms (for patients)

• clinically relevant alterations in blood draw, ecg, and somatic testing

• substance dependency disorder

• intake of psychopharmacological medication in last 6 months

• first degree relative with Axis 1 disorder (for Pilot I study)