Post Burn Pruritus Study in Patients Undergoing Wound Healing

• Status: Completed
• Trial end date: 2006-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to see if a drug called ondansetron (Zofran) controls itching from healing burn wounds as well or better than the usual drug used, diphenhydramine (Benadryl).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: United States Army Institute of Surgical Research
• Treatments: Diphenhydramine; Ondansetron; Promethazine

Criteria

Inclusion Criteria:

• Males or females; 18 years or older.

• Seen in the United States Army Institute of Surgical Research (USAISR) Burn Clinic with healing burn wounds of any percent (%) of total body surface area (TBSA) causing pruritus

• Stable medical condition

• Negative pregnancy test and not nursing

• Able to indicate status of pruritus on a numeric scale

• Able to understand and read English

Exclusion Criteria:

• Unstable medical condition as determined by attending burn surgeon

• Prisoner

• History of allergic reaction to serotonin inhibitors or diphenhydramine

• Pregnant or lactating

• Unable to verbalize pruritus intensity scale

• Unable to understand or read English