Post- Myocardial Infarction Arterial Wall Improvement by Low-dose Fluvastatin and Valsartan
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
The concept of improving arterial wall characteristics by treatment with a very low-dose
combination of fluvastatin and valsartan (low-flu/val) in stable, post-myocardial infarction
(MI) patients was tested. The parameters of endothelial function (flow mediated dilatation
(FMD), reactive hyperemia index) and arterial stiffness (carotid-femoral pulse wave velocity
(cf-PWV), local carotid PWV and β-stiffness coefficient) were measured before and after 30
days of treatment, and the residual effect was assessed 10 weeks later. So the investigators
explored whether low-flu/val added "on-top-of" optimal therapy could improve endothelial
function and arterial stiffness in post-MI patients. Since these improved parameters are
well-known predictors of future coronary events, such treatment could decrease cardiovascular
risk.