Post Operative Sore Throat and Dexamethasone

• Status: Completed
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

Sore throat is a common postoperative complaint that can lead to morbidity and patient dissatisfaction . The incidence of sore throat has been reported to be between 6% and 90% even under optimal intubating conditions. There are several factors that have been shown to contribute to postoperative sore throat such as patient related factors, type of anesthesia and type of surgery.

Corticosteroids are also commonly used in the perioperative period to potentiate analgesics and as antiemetics. The preoperative administration of dexamethasone can decrease the incidence and severity of postoperative sore throat which is rated by patients as one of the most undesirable outcomes in the postoperative period.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwestern University
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Female patients undergoing outpatient laparoscopic gynecologic surgery

• ASA PS I and II

• Age between 18 and 64 years

• Fluent in English

Exclusion Criteria:

• History of recent respiratory tract infection

• Pregnancy, breastfeeding

• Current treatment with analgesics

• Current use of corticosteroids

• Anticipated difficult intubation

• Risk factors for post-operative aspiration