Post-op Ketamine Study

• Status: Unknown status
• Trial end date: 2019-04-27
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption. We hypothesize that sub-anesthetic ketamine will decrease post-operative pain and narcotic consumption and may secondarily lead to shorter lengths of stay, faster rehabilitation, improved postoperative outcomes and patient satisfaction.

• Phase: N/A

Details

• Lead Sponsor: Rothman Institute Orthopaedics
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• 18 - 85 years of age

• ASA I - IV

• Undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia

Exclusion Criteria:

• BMI over 40*

• Contraindication or allergy to opioid pain medication or ketamine*

• Daily opioid use for pain control before surgery in excess of systemic morphine equivalent to 10 mg*

• Ejection fraction (EF) less than 30%

• Creatinine clearance less than 30 mL/min*

• History of chronic liver failure

• Desire for nerve block or general anesthesia

• Any neurologic or psychiatric disorder (including bipolar disorder, post traumatic stress disorder, schizophrenia)

• Prior surgery on ipsilateral knee within the last 6 months

• Alcohol abuse