Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs

• Status: Not yet recruiting
• Trial end date: 2023-12-31
• Target enrollment: 0
• Participant gender: All

Summary

While studies have shown improved postoperative pain control with TAP blocks after inguinal and ventral hernia repair, data comparing Liposomal bupivacaine (Exparel) to bupivacaine alone in formulation of the TAP block is particularly scarce. Therefore, we designed a prospective, randomized trial comparing the postoperative pain control in minimally invasive ventral and inguinal hernia repair patients who receive an Exaparel-based TAP block compared to the traditional bupivacaine (Marcaine) TAP block.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Leslie Son
• Collaborator: Our Lady of the Lake Regional Medical Center
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• 18 years of age or older

• Have a ventral or inguinal hernia requiring surgical repair

Exclusion Criteria:

• Less than 18 years of age

• Chronic pain patients

• Having a defect >10 cm in transverse dimension

• Having a defect <4 cm

• Has an allergy to bupivacaine

• Has recurrent hernias as per medical history

• A TAP block performed at any time aside from just prior to the start of the procedure

• If bupivacaine is mixed with other anesthetics

• Under the instance of an emergency surgery (trauma)

• Concomitant surgery

• History of EtOH abuse

• History of liver/kidney dysfunction

• If the procedure must be converted to open

• Inidividual's weight < 50kg

• Individual's BMI > 45