Post-preeclampsia Renal Project: Study of Nephroprotection in Women Having Suffered Preeclampsia

• Status: Completed
• Trial end date: 2018-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of the Post-preeclampsia Renal Project is to investigate the renal function of preeclamptic women after delivery, and to determine whether the anti-hypertensive drug named benazepril efficiently improves the dysfunctions observed.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Geneva
• Treatments: Benazepril

Criteria

Pre-selection Criteria:

• Normotensive women with no proteinuria before the 20th week of gestation AND

• Women with hypertension (BP ≥140/90 mm Hg) and proteinuria (≥ 0.3 g /24h or 2++ dipstick) after the 20th week of gestation

Inclusion Criteria:

• Clearance of creatinine ≤ 80 ml/min (Gault et Cockcroft)

• Serum creatinine ≥ 80 µmol/L

• Microalbuminuria comprised between 30 and 300 mg/d and/or a urinary spot with microalbuminuria/creatinine ratio ≥ 3.5 and/or macroalbuminuria (24h urinary albumin excretion ≥ 0.500 mg)

• BP ≥ 140/90 mm Hg OR ongoing antihypertensive treatment

• CRP ≥ 4 mg/dL

Exclusion Criteria:

• Those unlikely to co-operate in the study

• Those who refuse to use appropriate contraceptive measures during the treatment period (intrauterine device, oral contraceptives, condom, diaphragm)

• Those with a history of pre-term delivery

• Those with known history of severe allergic reaction

• Those who consume drugs

• Aged < 18 years old