Postdural Puncture Headache Relief With Aminophylline and SPGB

• Status: Not yet recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of the study is to compare Sphenopalatine ganglion block (SPGB) and aminophylline in the efficacy and safety management of PDPH.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Aminophylline

Criteria

Inclusion Criteria:

• 18 - 40 years old female.

• ASA I -II according to the American society of anesthesiologists.

• Spinal anesthesia with 22G Quincke needle for cesarean section.

• PDPH was defined according to the international classification of headache disorders, 3rd edition criteria (ICHD-3) as:

• Headache occurring within 5 days of a lumbar puncture.

• Orthostatic headache that significantly worsens soon after sitting upright or standing and/or improves after lying horizontally usually accompanied by neck pain, tinnitus, changes in hearing, photophobia, and/or nausea.

• Exclusion of other causes such as hypertension, preeclampsia, tension headache, migraine, etc.

Exclusion Criteria:

• A history of headaches that could interfere with the PDPH diagnosis,

• A history of central nervous system diseases, including intracranial hemorrhage, seizures, intracranial hypertension, or hydrocephalus

• A history of cardiovascular diseases, including coronary heart disease, arrhythmias, or hypertension.

• A history of allergy to or any contraindication for using Aminophylline.

• Coagulopathy.

• Nasal septal deviation, polyp, or nasal bleeding.

• General anesthesia after failed spinal anesthesia.