Postmenopausal Women and Their Endothelium

• Status: Recruiting
• Trial end date: 2024-09-03
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to test the effects of a one time dose of inorganic nitrate (supplied in the form of beetroot juice) on blood vessel function and resting blood pressure in healthy, postmenopausal women who are within 5 years of menopause. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Penn State University

Criteria

Inclusion Criteria:

• Early post-menopausal women who are within 1-5 years following their final menstrual period

Exclusion Criteria:

• Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s).

• Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)

• Individuals with a BMI > 35

• Individuals with resting blood pressure > or = 130/80 mm Hg

• Individuals with high blood lipids (total cholesterol > or = 240 mg/dl, LDL > or = 160 mg/dl, triglycerides > or = 200 mg/dl).

• Postmenopausal women with hyperglycemia (fasting glucose > or = 110 mg/dl and HbA1c >6.0%).

• Individuals taking any of the following medications:

1. blood pressure lowering medication (e.g., beta blockers, ACE inhibitors, angiotensin antagonists, calcium channel blockers, diuretics)

2. lipid- lowering medication (e.g., statins)

3. nitrates (e.g. nitroglycerin) for angina

4. phosphodiesterase inhibitors (e.g., Viagra)

5. anti-Inflammatory drugs

• Individuals taking hormone therapy