Postoperative Analgesia After Total Knee Arthroplasty
Status:
Terminated
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain.
Although epidural treatment provides good and reliable postoperative pain relief after THA,
it may cause urinary retention, nausea, hypotension, diminished muscle control, and delayed
mobilization.
The challenge of new analgesic regimes is to reduce the occurrence of side effects while
maintaining adequate pain relief and maximum muscle control. A relatively new method to
provide postoperative pain relief after TKA is local infiltration analgesia combined with
single-shot injection(s) or continuous infusion of local anesthetics into the surgical site.
As local infiltration analgesia combined with continuous intraarticular infusion compared
with continuous epidural infusion has not been evaluated, our study was designed to determine
whether this technique could enhance analgesia and improve patient outcome after TKA. This
study compares continuous epidural infusion of Ropivacaine and intravenous Ketorolac with
local infiltration analgesia with Ropivacaine, Ketorolac and Adrenaline combined with
continuous intraarticular infusion of Ropivacaine and Ketorolac.