Postoperative Aspirin and Ankle Fracture Healing

• Status: Recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to identify if postoperative aspirin use leads to a delay in fracture healing. NSAIDs have long been avoided in the management of fractures, due to the belief that they may impair fracture healing. As aspirin is frequently prescribed for long-term management of various medical conditions, it is worth understanding if continuing to take aspirin during the process of fracture healing has a clinically significant effect on the rate of fracture healing.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• Over 18 years of age

• healthy enough for orthopedic surgery

• slated to undergo surgical repair of ankle fracture at UAB

• able to give consent All ankle fractures (lateral malleolus, medial malleolus, bimalleolar, trimalleolar, and proximal fibula) will be included in this study.

Exclusion Criteria:

• Under 18 years of age

• inability to give consent

• Pilon fractures

• Multiple traumatic fractures

• Known history of aspirin allergy

• History of severe reaction to aspirin

• History of bleeding disorder

• Other clear contraindication to being prescribed aspirin

• Taking blood-thinning medications (heparin, apixaban, etc)

• Taking aspirin prior to the start of the study