Postoperative Effects of Propofol Versus Sevoflurane Anesthesia

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life.

Objectives: To compare the efficacy and safety of propofol versus sevoflurane in patients undergoing elective, non-cardiac operations under general anesthesia.

Methods: This was a randomized (1:1), parallel, phase four clinical trial; carried out on 44 patients, who were candidates for elective, non-cardiac operations under general anesthesia at our hospital. Patients were randomly allocated into two equal groups in which anesthesia was maintained with propofol infusion in group P and sevoflurane inhalation in group S.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Damanhour Teaching Hospital
• Treatments: Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status ≤ II

• Age from 21 years

• Body Mass Index (BMI) 25-35 kg/m2

Exclusion Criteria:

• ASA physical status > II

• Age < 21 years

• Patients with Montreal Objective Cognitive Assessment (MoCA-B) score < 24 points

• Patients with significant cardiovascular, cerebrovascular, respiratory, liver, renal, endocrine, blood, or immune diseases

• Patients with visual or auditory disease, infection, chronic inflammation, disturbance of consciousness, cognitive impairment, or dementia

• Patients on long-term use of sedatives or steroids, alcohol or drug abuse

• Allergy to any of the study drugs