Postoperative Opioid Use and Pain Scores in Patients Undergoing Transforaminal Lumbar Interbody Fusion

• Status: Terminated
• Trial end date: 2018-01-11
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to study the effects of preoperative followed by scheduled intravenous acetaminophen on pain control for 24 hours postoperatively after minimally invasive 1 or 2 level transforaminal lumbar interbody fusion.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Texas Tech University Health Sciences Center
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Age > 18 years old

• Being scheduled to have elective primary minimally invasive 1 or 2 level transforaminal lumbar laminectomy interbody fusion

• ASA I, II, or III

• Informed consent form signed

Exclusion Criteria:

• Anyone weighing less than 50kg (as this would require a dosing change).

• Hypersensitivity or contraindication to intravenous acetaminophen or opioids

• Allergy to Methocarbamol; morphine sulfate, sevoflourane, or fentanyl

• Impairment of liver function-- defined as the inability to receive intravenous acetaminophen without dose adjustment as determined by the investigator; or history of chronic liver disease defined as history of hepatitis of any kind as recorded in the patient's chart

• Mental retardation recorded as a diagnosis in the patient's chart

• History of chronic pain (defined as currently receiving treatment from a specialist for pain)

• History of pain recalcitrant to intravenous morphine

• Impaired kidney function (defined as creatinine > 1.5)

• Anyone who is not a candidate for general anesthesia or any other portion of the investigator's standard of