Postoperative Pain Therapy With Hydromorphone Using TCI-PCA

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Treatment of postoperative pain with hydromorphone (a strong analgesic) using patient-controlled analgesia with target concentrations in blood compared to conventional patient-controlled analgesia after planed cardiac surgery

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Erlangen-Nürnberg Medical School
• Collaborator: German Federal Ministry of Education and Research
• Treatments: Hydromorphone

Criteria

Inclusion Criteria:

• Written informed consent

• Age between 40 and 85 years, both genders

• Scheduled for elective cardiac surgery involving thoracotomy and subsequent ICU stay

Exclusion Criteria:

• Administration of other analgesics or sedatives, if not administered in stable dosage for at least 14 days or if not used for premedication and surgery

• Administration of hydromorphone in the period between screening and surgery

• Severe hepatic or renal impairment in medical history

• BMI ≥35 kg/m²

• ASA ≥4