Postoperative Pain and Angiotensin II Receptor Antagonists

• Status: Unknown status
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: All

Summary

An angiotensin II type 2 receptor (AT2R) antagonist has been assessed for its efficacy in neuropathic pain with promising results. A considerable number of patients undergoing surgery under general anesthesia are hypertensive and receive drugs to control high blood pressure, including angiotensin II receptor antagonists. These drugs may attenuate the acute and/or chronic postoperative pain or decrease the analgesic requirements after surgery. The aim of the present study is to assess the early postoperative pain and analgesic requirements in patients treated with antagonists of the angiotensin II receptors for at least three months before surgery compared to normotensive patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Athens
• Treatments: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen

Criteria

Inclusion Criteria:

• Patients aged between 35 and 79 years

• ASA II or III

• BMI ≤ 35

• Elective abdominal surgery Exclusion Criteria:-

• Patients on analgesic, antidepressive, or sedative consumption during the last month

• Mental impairment

• Not speaking fluently Greek language

• Refuse to give written informed consent

• Diabetics

• Patients receiving antihypertensive treatment other than angiotensin type II receptor (AT2R) antagonists