Postoperative Vomiting in Children: Comparison Tri - Versus bi -Prophylaxis

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the benefit of addition of droperidol to prophylaxis with ondansetron and dexamethasone in children with high risk of postoperative vomiting (POV). In adults some authors showed that the effectiveness of prophylaxis is correlated to the number of molecules or specific procedures used.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Droperidol; Ondansetron

Criteria

Inclusion Criteria:

• Children scheduled for surgery and with high risk of postoperative vomiting, i.e. with VPOP score up to 4

• Between 3 to 18 years

• Informed consent signed or the owner (s) of parental

• Children receiving a social security system

Exclusion Criteria:

• Ambulatory surgery

• Preoperative corticosteroids

• Postoperative sedation

• Allergy known to droperidol, ondansetron or dexamethasone

• Known hypokaliemia

• Known hypomagnesemia

• Bradycardia (<55 bpm)

• Congenital long QT syndrome

• Treatment that induce prolonged QT

• Pheochromocytoma

• Severe depressive syndrome