Postpartum NSAIDS and Maternal Hypertension

• Status: Recruiting
• Trial end date: 2022-12-11
• Target enrollment: 0
• Participant gender: Female

Summary

Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period. NSAIDs remain part of standard postpartum care in women with hypertensive disease. The objective of this study is to determine whether postpartum standard care withholding NSAID use is associated with a clinically significant reduction in postpartum hypertension in women with pregnancy induced hypertension. The investigators hypothesize that women with pregnancy induced hypertensive disease will be half as likely to have blood pressure elevation of 150/100 mmHg in the first 24 hours postpartum.

This study is an open label randomized trial of women with antepartum hypertension. Women will be randomized to receive standard postpartum care or standard postpartum care without NSAIDs. Blood pressure measurements and patient outcomes will be recorded. The study period will begin at the time of delivery and will end at the time of hospital discharge.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Southern California
• Treatments: Anti-Inflammatory Agents, Non-Steroidal; Ibuprofen

Criteria

Inclusion Criteria:

• Women 18 years or older delivering at LAC/USC Hospital

• Delivery occurring at or after 20 weeks gestation

• Diagnosis of antenatal hypertensive disorder: gestational hypertension, preeclampsia without severe features, preeclampsia with severe features, superimposed preeclampsia, eclampsia, chronic hypertension

Exclusion Criteria:

• HELLP Syndrome

• Renal dysfunction (Serum Creatinine >1.1 in current pregnancy)

• Known liver disease

• Low platelet count (<50,000 during hospital admission)

• Known sensitivity or allergy to ibuprofen or acetaminophen

• Use of therapeutic doses of anticoagulation

• Postpartum hemorrhage requiring blood transfusion

• Neonate with platelet disorder or thrombocytopenia in breastfeeding mother