Postprandial Blood Glucose Control and Gastric Emptying in Type 1 Diabetes: Pathogenetic Factors and Therapeutic Options

• Status: Unknown status
• Trial end date: 2016-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the prevalence of gastric emptying (GE) in type 1 diabetic patients (DM1) free of chronic complications in comparison with a group of healthy control subjects. The investigators will also assess the relationship between GE and glucose control (HbA1c, postprandial glucose variability), gut peptide hormones (GLP-1, GIP, and ghrelin), and gastrointestinal symptoms.

In addition, in patients with delayed GE the investigators will investigate the effect of "tailored" pre-prandial insulin bolus administered by means of insulin pump in reducing postprandial glucose variability, evaluated through continuous glucose monitoring system.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Federico II University
• Treatments: Hormones; Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• DM1;

• Use of insulin pump;

• Disease duration ≥ 3 years.

Exclusion Criteria:

• Presence of chronic complications of DM (including cardiovascular autonomic neuropathy);

• BMI ≥ 30 kg/m2;

• Presence of chronic diseases other than DM1;

• Diseases that interfere with GE;

• Medications that interfere with blood glucose homeostasis (except insulin) and GE.