Postprandial Lipidemia After a Meal With Different Types of Fat, Estrogen Treatment, Age and Gender in Healthy Subjects

• Status: Unknown status
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The study examines the effect of hormone replacement in postmenopausal women compared to men, 55 years of age, and in the elderly without hormone replacement of both sexes. The lipid and glucose metabolism is evaluated during treatment and placebo with a meal with mashed potatoes and different types of fat. Glucose, insulin, triglyceride, total cholesterol, LDL and HDL cholesterol, free fatty acids and coagulation parameters are measured.

During menopause the women reduce their levels of estrogen and their risk of cardiovascular disease rises to the men's level. This effect on mortality and morbidity can probably be reduced by hormone therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Herning Hospital
• Collaborator: Sygehus Lillebaelt
• Treatments: Estradiol; Estrogens

Criteria

Inclusion Criteria:

• Men, age 45-55

• Men age 65-80

• Women age 45-55: The menopausal women's follicle stimulating hormone and luteinizing hormone levels should be above 40 nmol/l

• Women age 65-80

Exclusion Criteria:

• hypercholesterolemia,

• hypertension,

• substance abuse or alcohol abuse

• recognized renal, hepatic, cardiac and metabolic disorders,

• thromboembolic diseases,

• active cancer of the uterus or breast or

• other hormone replacement therapy.

• If pronounced side effects of hormone treatment, the subject is omitted from the trial