Pot-Kast: Thrombosis Prophylaxis After Knee Arthroscopy
Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
Currently, guidelines and clinical practice differ considerably with respect to use of
anticoagulant treatment after arthroscopy of the knee. Trials that have been carried out were
aimed at efficacy only, had small sample sizes and therefore mainly used asymptomatic
thrombosis as endpoint. From these trials an overall risk benefit-balance could not be
established, hence the current controversy. In the proposed study the investigators will use
relevant symptomatic endpoints in a large cohort of patients. Furthermore the investigators
will follow subjects with an adverse event for a longer period, during which the
investigators will assess the long term sequelae of these events. Lastly, the investigators
will determine high risk groups that will benefit most from anticoagulant treatment.
Objective: Comparative effectiveness research to determine cost-effectiveness of two existing
policies, i.e. treatment with low molecular weight heparin (LMWH) after arthroscopy of the
knee. In addition the investigators will investigate personalized prophylaxis based on
genetic and acquired risk factors.
Phase:
N/A
Details
Lead Sponsor:
Suzanne C. Cannegieter, MD PhD
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development