Potential Role for Carbon Nanoparticles to Guide Central Neck Dissection in Patients With Papillary Thyroid Cancer

• Status: Completed
• Trial end date: 2016-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Papillary thyroid cancer (PTC) is the most common subtype of thyroid cancer.

The most common site of PTC nodal metastases is the central neck, which has a reported rate of lymph node metastases as high as 50%~70%.

Central neck dissection has important value to ensure accurate clinical staging and surgical planning.

As a novel lymphatic tracer, carbon nanoparticles (CN) have been applied successfully in the detection of sentinel lymph nodes in breast and gastric cancers, while not been used as a lymphatic tracer for PTC. The goal of this study was to evaluate whether the use of CN facilitates the detection of lymph nodes, increases the number of metastatic lymph nodes removed, accurately reflects the metastatic condition of the central neck, and has the potential to protect the parathyroid glands.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Cancer Hospital

Criteria

Inclusion Criteria:

• All patients were diagnosed with PTC by preoperative fine needle aspiration cytology,

• Underwent the initial operation in our department, and had all tumors located in one lobe.

• PTC with a tumor between 1 and 4 cm

Exclusion Criteria:

• Nonthyroid cancer,

• Previous thyroid or parathyroid surgery

• Preoperative hypoparathyroidism or hypocalcemia

• Pregnancy or lactation

• Presence or suspicion of lateral neck lymph node metastasis,

• Age under 18 years

• Noncompliance with the follow-up protocol