Povidone-Iodine Rinses as an Adjuvant Therapy Post-Operatively

• Status: Not yet recruiting
• Trial end date: 2021-02-10
• Target enrollment: 0
• Participant gender: All

Summary

Povidone Iodine solution is a nasal antiseptic. Its application has been shown to be clinically safe, tolerable and effective against bacteria and fungi associated with chronic rhinosinusitis.

The purpose of this study is determining the effectiveness of PVP-I in comparison to a placebo for post-operative refractory CRS patients in a randomized controlled trial.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Paul's Hospital, Canada
• Treatments: Cadexomer iodine; Iodine; Pharmaceutical Solutions; Povidone; Povidone-Iodine

Criteria

Inclusion Criteria:

• 19 years or older

• Undergoing FESS at St. Paul's Hospital or False Creek Surgical Centre

Exclusion Criteria:

• Patients with sinonasal tumors.

• Patients who previously used PVP-I rinses - Patients with autoimmune diseases affecting the upper airway

• eg Systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis etc.

• Immuno-compromised patients, and patients with impairment in mucociliary function

• (e.g., cystic fibrosis, Kartagener syndrome)

• Hypersensitivity to iodine

• History of thyroid disorders including thyroid cancer, hyperthyroidism and hypothyroidism

• Use of medications for thyroid disorders including thyroxine and carbimazole

• Pregnancy

• Patients unable to speak English.