Mild traumatic brain injury (mTBI) caused by blast effects of explosive devices has been
called the "signature injury" of soldiers who served in the Iraq and Afghanistan conflicts.
mTBI can also occur from impact or hitting the head on an object or the ground. Although
termed "mild" in comparison to major brain injuries, people with mTBI can have problems with
their memory and concentration. People with mTBI can also find they are more irritable, have
more anxiety, and have trouble with their mood and sleep.
The purpose of this study is to see if a medication called prazosin can help treat chronic
headaches in people with mTBI. The Food and Drug Administration (FDA) has approved prazosin
for treating people with high blood pressure. At this time, the FDA has not approved prazosin
in the treatment of mTBI or headaches. Some people who have posttraumatic stress disorder
(PTSD) and have been taking prazosin for their medical conditions or who have taken it in
research studies have said they have fewer headaches.
Phase:
Phase 4
Details
Lead Sponsor:
Seattle Institute for Biomedical and Clinical Research
Collaborators:
Madigan Army Medical Center VA Puget Sound Health Care System