Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS

• Status: Unknown status
• Trial end date: 2018-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to evaluate systematic pre-antiretroviral cryptococcal antigen screening and pre-emptive fluconazole therapy in antigen positive patients, as a strategy to reduce morbidity and mortality due to AIDS associated cryptococcal meningitis in patients starting antiretroviral therapy at <100 CD4 in Cameroon.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: ANRS, Emerging Infectious Diseases; French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
• Collaborators: St George's, University of London; Yaounde Central Hospital
• Treatments: Anti-Retroviral Agents; Fluconazole

Criteria

Inclusion Criteria:

• Age ≥ 18years

• HIV 1 and 2 infected but naïve to ART

• CD4 cell count less than 100 cells/ml

• No documented past history of cryptococcal meningoencephalitis

• Acceptance to participate in the study

• Ambulatory/out patients.

Exclusion Criteria:

• Patients on ART

• Pregnant patients

• Patients with other severe AIDS-associated opportunistic infections