Pre-emptive Effect of Duloxetine in the Second Knee in Staged Total Knee Arthroplasty
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
In Korea, the interval between knee arthroplasties is usually 1 week. According to previous
studies, when total knee arthroplasty was performed at 1-week intervals, total bleeding was
reduced and the period of hospital stay was shortened.
However, if stepwise total knee arthroplasty is performed at intervals of one week, the pain
is greater after the second operation, and the reason for this phenomenon is known to be due
to central sensitization and opioid resistance.
Therefore, the investigators aim to confirm whether Duloxetine reduces the central
sensitization as previously known and affects the pain control after the second operation.