Pre-emptive Pregabalin on Attenuating Maternal Anxiety And Stress Response To Intubation During Caesarean Section

• Status: Recruiting
• Trial end date: 2021-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

There is exaggerated neuroendocrine stress response to laryngoscopy and endotracheal intubation during the Induction to anesthesia-delivery (I-D) period under light anesthesia. Mechanical stimulation of laryngeal proprioceptors elicits increased secretion of cortisol and catecholamine with subsequent elevation of blood pressure from 40 to 50 % and heart rate up to 20 % during direct laryngoscopy and endotracheal intubation

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zagazig University
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

• Age: 21-38 years old.

• Pregnant Female with a singleton fetus of at least 36 weeks of gestation.

• American Society of Anesthesiologist Physical status: 1& II.

• Body Mass Index (BMI) (25-30kg/m²).

• Type of operations: elective caesarean section under general anesthesia.

• Written informed consent from the parturient.

Exclusion Criteria:

• Altered mental state.

• Women with known history of allergy to pregabalin.

• Women with uncontrolled diabetes mellitus, bleeding, coagulation disorders, Hepatic, renal, Cardiovascular, respiratory disease and neuropsychiatric disorders.

• Patients receiving anticonvulsants, antidepressants.

• Pregnancy induced hypertension, intrauterine growth restriction or fetal compromise