Pre-reinductive Decitabine and Vorinostat in Relapsed Lymphoblastic Lymphoma or Acute Lymphoblastic Leukemia
Status:
Terminated
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer
cells, either by killing the cells or by stopping them from dividing. Decitabine and
vorinostat may alter the cancer cells by reversing the cancer pathways needed for cell
growth. Giving more than one drug (combination chemotherapy) together with decitabine and
vorinostat may kill more cancer cells than with chemotherapy alone.
PURPOSE: This phase II trial is studying how well giving decitabine and vorinostat together
with combination chemotherapy works in treating patients with acute lymphoblastic leukemia or
lymphoblastic lymphoma that has relapsed or not responded to treatment.